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KMID : 0604520120380020147
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 2 p.147 ~ p.154
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Elastic Liposome Formulation for Transdermal Delivery of Rutin
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Lim Myoung-Sun
Han Seat-Byeol
Kwon Soon-Sik
Park Min-A
Park Soo-Nam
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Abstract
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In this study, we prepared elastic liposome containing rutin, known as antioxidants, and evaluated the physical characterization and enhanced skin permeation effect. The elastic liposome was prepared using the different ratios of egg phospholipids and Tegoⓡ care 450. The mean diameter of rutin loaded elastic liposomes formulations ranged between 205.7 ∼ 298.0 nm and deforability 20.9 ∼ 42.5, The loading efficiency was observed to be 52.0 ∼ 71.0 %. The highest loading efficiency (71.0 %) and deformability (42.5) were observed at the optimal ratio of 85 : 15 (egg phospholipids : Tegoⓡ care 450) in the 0.1 % rutin loaded elastic liposome formulations. The elastic liposome formulation was selected for further transdermal permeation study. The elastic liposome(129.9 μg/cm2) exhibited a significantly higher skin permeation compared with general liposome (98.0 μg/cm2) and 1,3-butylene glycol (76.3 μg/cm2) solution. These results suggest that the elastic liposome formulation using Tegoⓡ care 450 as a major edge activator could be useful for the delivery of active ingredient through the skin barrier.
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KEYWORD
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rutin, elastic liposome, in vitro skin permeation, deformability, transdermal delivery systems
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